The local favorite has already seen its fair share of fame after winning various best-of-Boston pizza lists over the years. Santarpio's, which opened in 1903, sticks to their traditional roots when it comes to the infamous slightly chewy and satisfyingly wet slices. Their menu consists of a variety of options but includes a list of customers' favorite combos, like a pie that pairs sausage with garlic, ground beef, and onions, and even "The Works": mushrooms, onions, peppers, garlic, sausage, pepperoni, extra cheese, and anchovies. First-timer? Order Santarpio’s most popular pie — mozzarella, sausage, and garlic — to establish a baseline.