Preheat the oven to 350 degrees. In a small bowl, combine the 2 tablespoons ketchup with Worcestershire sauce.
In a medium skillet, heat the olive oil over medium-high heat. Sauté the onions until translucent.
In a medium bowl, mix together the turkey, sautéed onion, breadcrumbs, egg, 1/4 cup ketchup, Italian seasoning, and salt. Place mixture into a loaf pan and shape to fit. Spoon the reserved sauce over the meatloaf.
Bake uncovered for 55-60 minutes, remove from oven, and let it sit for 5 minutes before slicing.