Arguably the most beautiful hotel on this list, the Four Seasons in Florence was once the Palazzo della Gherardesca and many of the hotel’s most striking features date back to the 15th century. A short walk from the Duomo, this hotel is set in immaculate gardens and the walls of the hotel's chapel (now a reading room) were painted by Flemish Mannerist artist Jan van der Straet.
Some of the most exceptional interiors can be found in the $20,000-a-night Royal Suite, which contains an original 18th century ceramic floor by Ignazio Chiaiese and Venetian glass chandeliers.
Arguably, the Four Seasons is as much a museum as a hotel, and the seven-year renovation to restore two former palaces to their Renaissance glory was overseen by the Italian government department responsible for the maintenance of historical art and architecture.
The hotel spa is another highlight, with 10 luxurious treatment rooms and products made by the Officina Profumo-Farmaceutica di Santa Maria Novella, where monks have mixed potions from Tuscan flora and fauna since the 13th century.