The long journey of the tomato from wild weed to your dinner plate starts in the middle Paleolithic era when these wild tomatoes were growing (potentially) unchecked.
Around 80,000 years ago, the wild tomato evolved in Ecuador and Peru. These ancient people didn't do much domesticating, but somehow, the seeds made their way to southern Mexico.
This belief came from the fact that a popular medieval poison, bittersweet nightshade, has clusters of toxic red berries resembling wild "pimp" and early lycopersicum tomatoes.
The leaves and stems of a tomato plant contain solanine. In large quantities, this glycoalkaloid poison can cause symptoms from GI distress to paralysis, hallucinations, and death.
Once they figured out how to properly eat the tomatoes, aristocrats would eat them off their deadly, lead-containing pewter plates, gaining an unwarranted bad rap for the fruit.