Lean, flavorful bison is a great alternative to roast beef in this easy one-pot dish. Serve with a side of salad greens for a balanced meal.
Preheat the oven to 375 degrees.
Coat a roasting pan with cooking spray. Combine the ketchup, mustard, honey, chili powder, cumin, and salt in a medium-sized bowl. Mix well to combine. Add in the liquid smoke, if using.
Place the bison in the roasting pan and coat the entire surface with the ketchup mixture. Using a sharp knife, make several pricks in the roast to allow the coating to get inside (about ¼-inch-deep). Arrange the potatoes around the roast.
Roast until a meat thermometer inserted in center of meat reads 140 degrees, about 1 hour (for medium-rare). Let the bison stand for 10 minutes before slicing crosswise into ¼-inch-thick slices. Serve with potatoes on the side.