Serve this big, delightfully puffy pancake right from the skillet, or transfer it to a platter by running a knife around the edges and then loosening the bottom with a spatula before sliding the pancake onto a platter.
Preheat oven to 425 degrees. Place butter in a large (11- or 12-inch) cast-iron or ovenproof skillet and heat in the oven until butter is melted, about 3 minutes.
Meanwhile, in a blender, combine eggs, milk, cane sugar, cinnamon, and salt. Blend until smooth. Add flour and blend again. Remove skillet from oven, swirl butter to coat the bottom and sides of the pan, and pour in the batter. Top with pears and bake until the pancake is puffed and browned and pears are tender, 18 to 20 minutes. Sprinkle with powdered sugar and cut into wedges for serving.