Boil the macaroni in a 2-quart saucepan in plenty of water until tender, about 7-9 minutes. Drain. In a medium saucepan, mix butter and cheeses (reserve 1/4 cup of the Cheddar). Stir until the cheeses melt. Add the sour cream, salt, milk, mustard, garlic powder, and pepper to the butter/cheese mixture and stir well. Then add drained macaroni and mix well. Pour into a baking dish coated with nonstick spray. Sprinkle with remaining Cheddar cheese and breadcrumbs. Bake, uncovered at 350 degrees for 35-40 minutes or until golden brown and bubbly.